alt

徐学清个人信息

性别:男                                                      出生日期:1978.01

学历:博士                                                   籍贯:湖北?咸宁

手机:13928746164                                     Email: Xu2003@smu.edu.cn

受教育经历

09/2004-07/2007   中国科学院,昆明动物研究所,博士

09/2001-07/2004   南京农业大学,动物医学院,硕士

09/1997-07/2001   湖北农学院,动物科学系,学士

研究工作经历

12/2012-目前       南方医科大学,药学院,副教授

10/2009-09/2012   美国国立卫生研究院,过敏原与传染病研究所,博士后

05/2009-09/2009   美国弗吉尼亚大学,药学院,博士后

07/2007-05/2009    南方医科大学,药学院,讲师

获奖情况:

1. 霍英东青年教师奖(三等奖),霍英东教育基金会,2010

2. 优秀科技论文特等奖(获奖人排名:徐学清、杨海龙、马东莹、武静、赖仞),云南省科学技术协会,2010

3. 云南省科学技术奖突出贡献类自然科学一等奖(获奖人排名:赖仞、张云、李建许、张亚平、郑永唐、徐学清、杨海龙、李文辉),云南省政府,2008

4. 先进工作者荣誉称号;南方医科大学,2008

5.  院长奖优秀奖,中国科学院,2007

课题申情况

  1. 蛴螬活血化瘀的分子机制研究,批准号:30800185;国家自然科学金,2009年1月-2011年12月,项目负责人,资助额度:20万;

  2. 印鼠客蚤FS50肽抑制Nav1.5钠通道的结构基础和作用机制,批准号:31370782;国家自然科学基金,2014年01月-2017年12月,项目负责人,资助额度:80万元。

  3. 印鼠客蚤FS50肽抑制Nav1.5钠通道的结构基础和作用机制,广东省教育厅,优秀青年教师培养计划,2014年01月-2016年12月,项目负责人,资助额度:30-50万元。

  4. 吸血节肢动物唾液腺蛋白的结构与功能,南方医科大学杰青培养计划,2014年01月-2016年12月,项目负责人,资助额度:30万元。

研究经历

1. 吸血节肢动物唾液腺蛋白的结构功能关系研究;

2. 两栖动物皮肤、大胡蜂毒腺蛋白组学和多肽学研究;

3. 重组病毒的构建和DNA病毒疫苗的研发;

教学工作

1. 2007-2009,2012,2013年,主讲本科生专业课程《生物技术制药》,《抗病毒药物与分子病毒学》

2. 2008-2009,主讲本科生选修课程《美容药物学》

 

主要论著

表的SCI论文*为共享第一作者):

  1. Xu XChang BWMans BJRibeiro JMAndersen JF. The structure and ligand-binding properties of the biogenic amine-binding protein from saliva of a blood-feeding insect vector ofTrypanosoma cruziActa Crystallogr D Biol Crystallogr69(Pt 1): 105-13. 2013.(IF: 12.619)

  2. Li J*, Xu X*Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J. Anti-infection peptidomics of amphibian skin. Mol Cell Proteomics, 6(5):882-94, 2007IF 9.425

  3. Xu X,Yang H, Ma D, Wu J, Wang Y, Song Y, Wang X, Lu Y, Yang J, Lai R. Toward an understanding of the molecular mechanism for successful blood feeding by coupling proteomics analysis with pharmacological testing of horsefly salivary glands. Mol Cell Proteomics, 7(3): 582-90, 2008  (IF 8.834)

  4. Li J*, Zhang C*, Xu X*, Wang J, Yu H, Lai R, Gong W. Trypsin inhibitory loop is an excellent leadstucture to design serine protease inhibitors and antimicrobial peptides. The FASEB Journal, 21(10): 2466-73, 2007  (IF 7.2)

  5. Xu X, Oliveira F, Chang BW, Collin N, Gomes R, Teixeira C, Reynoso D, Pham VM, Elnaiem DE,Kamhawi S, Ribeiro JM, Valenzuela JG, Andersen JFStructure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity againstLeishmania major infection.Biol Che 286(37): 32383-93, 2011(IF: 5.328)

  6. Xu XFrancischetti IM, Lai R, Ribeiro JM, Andersen JFStructure of protein having inhibitorydisintegrin and leukotriene scavenging functions contained in single domain. Biol Chem, 287(14): 10967-76, 2012(IF: 4.773)

  7. Ma D*, Xu X*, An S, Liu H, Yang X, Andersen JF, Wang Y, Tokumasu F, Ribeiro JMFrancischettiIM, Lai R. A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets αIIbβ3 or αVβ3 and inhibits platelet aggregation andangiogenesisThrombosis and Haemostasis, 105(6):1032-45, 2011  (IF: 4.701)

  8. Xu X,Li J, Lu Q, Yang H, Zhang Y, Lai R. Two families of antimicrobial peptide from wasp (Vespamagnifica) venom. Toxicon,  47(2):249-53, 2006 (IF 2.6)

  9. Xu X, Li J, Han Y, Yang H, Liang J, Lu Q, Lai R. Two antimicrobial peptides from skin secretions ofrana grahamiToxicon, 47(4): 459-64, 2006IF 2.6

  10. Xu X, Yang H, Yu H, Li J, Lai R. The mastoparanogen from wasp. Peptides, 27(12):3053-7, 2006IF 2.6

  11. Yang H*, Xu X*, Ma D, Zhang K, Lai R. A phospholipase A1 platelet activator from the wasp venom of Vespa magnifica (Smith). Toxicon, 51(2):289-96, 2008 IF: 2.46

  12. Li J*,Xu X*, Yu H, Yang H, Huang Z, Lai R. Direct antimicrobial activities of PR-bombesinLife Sciences, 78(17):1953-6, 2006 IF 1.6

  13. Ma DWang YYang HWu JAn SGao LXu XLai R. Anti-thrombosis repertoire of blood-feeding horsefly salivary glands. Mol Cell ProteomicsMol Cell Proteomics. 8(9): 2071-9, 2009(IF:8.345)

  14. Ma DLi YDong JAn SWang YLiu CYang XYang HXu XLin DLai R. Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanus yao.Allergy,   66(1):101-9, 2011 (IF:6.297)

  15. An S, Chen L, Wei JF, Yang X, Ma D, Xu X,Xu X, He S, Lu J, Lai R. Purification and characterization of two new allergens from the venom of Vespa magnifica. PLoS One, 7(2): e31920, 2012IF: 4.1

  16. Li JWu HHong JXu XYang HWu BWang YZhu JLai RJiang XLin DPrescott MCRees HHOdorranalectin is a small peptide lectin with potential for drug delivery and targeting. PLoSOne, .3(6):e2381, 2008 (IF 4.41)

  17. Li JWu JWang YXu XLiu TLai RZhu H. A small trypsin inhibitor from the frog of OdorranagrahamiBiochimie, 90(9):1356-61, 2008  (IF 3.071)

  18. Ma DGao LAn SSong YWu J,Xu XLai R. A horsefly saliva antigen 5-like protein containingRTS motif is an angiogenesis inhibitor. Toxicon. 55(1): 45-51, 2010(IF 2.451)

  19. Qi ZPan CLu HShui YLi LLi X,Xu XLiu SJiang SA recombinant mimetics of the HIV-1 gp41prehairpin fusion intermediate fused with human IgG Fc fragment elicits neutralizing antibody response in the vaccinated mice. Biochem Biophys Res Commun, 398(3):506-12, 2010(IF: 2.595)

  20. Han JYou DLai R, Meng Q. An anticoagulant serine protease from the wasp venom of Vespa magnificaToxicon, 51(5): 914-22, 2008 (IF 2.46)

  21. Che Q, Zhou Y, Yang H, Li J,Xu X, Lai R. A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahamiPeptides, 29(4):529-35, 2008 (IF 2.654)

  22. Chen LLi YLi JXu XLai RZou Q. An antimicrobial peptide with antimicrobial activity againstHelicobacter pylori. Peptides, 28(8):1527-31, 2007  (IF 2.654)

  23. Li J, Yu H, Xu X,Wang X, Liu D, Lai R. Multiple bombesin-like peptides with opposite functions from skin of Odorrana grahamiGenomics, 89(3):413-8, 2007 (IF 3.327)  

  24. Wang XSong YLi JLiu HXu X,Lai RZhang K. A new family of antimicrobial peptides from skin secretions of Rana pleuradenPeptides, 28(10):2069-74, 2007(IF 2.654)

  25.  Lu YLi JYu HXu XLiang JTian YMa DLin GHuang GLai R. Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis,Peptides, 27(12):3085-91, 2006IF 2.46

  26. Li J, Liu T, Xu X, Wang X, Wu M, Yang H, Lai R. Amphibian tac, hykinin precursor, Biochemical and Biophysical Research Communications, 350(4): 983-6, 2006 (IF 2.9)

  27. Liang JHan YLi JXu XRees HHLai R. A novel bradykinin -peptide from skin secretions ofrufous-spotted torrent frog, Amolops loloensisPeptides, 27(11):2683-7, 2006IF 2.46

  28. Yu D, Sheng Z, Xu X,Li J, Yang H, Liu Z, Rees HH, Lai R. A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensisPeptides, 27(1):31-5, 2006IF 2.46

  29. Zhou Z, Yang H, Xu X,Wang XLai R. The first report of kininogen from invertebrates. BiochemBiophys Res Commun347(4):1099-102, 2006IF 2.648

授权发明专利

  1. 赖仞,徐学清.胡蜂抗菌肽及其制备方法和应用, 2009.04, 中国,200510010664.7

  2. 赖仞,徐学清,梁建国,韩曜平,杨海龙,李建许棕点湍蛙抗菌肽及其基因和在制药中的应用,2007.11, 中国,200610010627.0

  3. 赖仞,徐学清,梁建国,韩曜平,杨海龙,李建许棕点湍蛙活性多肽及其基因和在制药中的应用,2007.11, 中国,200710010628.3

  4. 赖仞,李健许,徐学清,杨海龙中华硬蜱神经肽及其制备方法和应用,2006.11, 中国,ZL 200510010665.1

  5. 赖仞,李建许,梁建国,徐学清,李东升,李宗杰无指盘臭蛙胰岛素释放促进肽和在制药中的应用,2006.03, 中国,ZL 200610010770.X

  6. 赖仞,李建许,徐春花,李宗杰,吕毅,李东升,徐学清,赖仞无指盘臭蛙丙精肽、基因和变异体,2008.05, 中国,ZL 200610010931.5

  7. 赖仞,李建许,韩曜平,李东升,梁建国,徐学清无指盘臭蛙丝氨酸蛋白酶抑制剂及其应用,2010.01, 中国,ZL 200610010930.0

  8. 赖仞,李建许,徐学清,徐春花,李东升,吕毅无指盘臭蛙抗菌肽2009.08中国,ZL 200610010928.3.

CURRICULUM VITAE

Xueqing Xu

Contact Information:

Schoolof PharmaceuticalSciences,

SouthernMedical University,

Guangzhou, China

Cell phone: 13928746164 15384419341

Email: xxueqing@yahoo.com.cn

Education and Career:

  1. 12/2012-present, Associate professor, School of Pharmaceutical Sciences, Southern Medical  University, Guangzhou, China

  2. 09/2012-12/2012, Lecturer, School of Pharmaceutical Sciences, Southern Medical  University, Guangzhou, China

  3. 10/2010-09/2012, Visiting fellow, Laboratory of Malaria and Vector Research NIH/NIAID, Bethesda MD, USA

  4. 05/2009-09/2010, Research associate, Microbiological Department of Medicine School, University of Virginia, Virginia, USA

  5. 07/2007-05/2009, Lecturer, School of Pharmaceutical Sciences, Southern Medical  University, Guangzhou, China

  6. 09/2004-07/2007, Ph.D. in Biochemistry and Molecular Biology, The Department of AnimalToxinologyKunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China

  7. 09/2001-07/2004, M.S. in Veterinary Microbiology and Immunology, The College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

  8. 09/1997-07/2001, B.S. in Veterinary , Hubei Agricultural College, Jingzhou, China

 

Awards

1.Young Teacher Award conferred by Fok Ying-Tung Education Foundation Committee and China Education department in 2010

2.Special award for Outstanding Scientific and Technological Thesis conferred by YunnanProvince Scientific Associationin 2010

3.  Research Excellence Award conferred by the Academic Committee of the Yunnan Province of China in 2008

4. Advanced worker Awardconferred by Southern Medical University  in 2008

5. Excellence Award of the Yuanzhang Scholarship conferred by The Chinese Academy of Sciences in 2007

 

Grants:

  1. Natural Science Foundation of China (NSFC) 30800185, Value:¥200k. Toward an understanding of the molecular mechanism of the grub promoting blood circulation and eliminating of blood stasis. Funding through 2009-2011

  2. Natural Science Foundation of China (NSFC) 31370782, Value:¥800k. Structure basis andmechansim of  fs50, a NaV1.5 inhibitor from the oritental flea (Xenopsylla cheopis (Rots). Funding through 2013-2017

  3. Guangdong Province Education Bureau plan for execllent teacher, Value:¥300k. Structure basis and mechansim of  fs50, a NaV1.5 inhibitor from the oritental flea (Xenopsylla cheopis (Rots). Funding through 2013-2016

  4. Excellent youth plan of southern medical university. Value:¥300k. Structure and function of proteins from the salivary glands of blood-feeding arthropod.   Funding through 2013-2016

 

Research Experiences:

  1. Structure and function of biologically active salivary proteins from blood-feeding arthropods.

  2. Exploration of proteomics and peptidomics of amphiban skin and wasp venom.

  3. Construction of recombinant virus and Development of the DNA vaccine

 

Teaching jobs

  1. In fall semester of 2007-2009 and 2012,Speaker in undergraduate required professional course “Biotechnological pharmaceutics”and “antivirial drugs and molecular virology”.

  2. In spring of 2008-2009,Speaker in undergraduate elective courses “Cosmetic Pharmacology”

 

Publications(* co-first author):

  1. Xu XChang BWMans BJRibeiro JMAndersen JF. The structure and ligand-binding properties of the biogenic amine-binding protein from saliva of a blood-feeding insect vector ofTrypanosoma cruziActa Crystallogr D Biol Crystallogr69(Pt 1): 105-13. 2013.(IF: 12.619)

  2. Li J*, Xu X*Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J. Anti-infection peptidomics of amphibian skin. Mol Cell Proteomics, 6(5):882-94, 2007IF 9.425

  3. Xu X,Yang H, Ma D, Wu J, Wang Y, Song Y, Wang X, Lu Y, Yang J, Lai R. Toward an understanding of the molecular mechanism for successful blood feeding by coupling proteomics analysis with pharmacological testing of horsefly salivary glands. Mol Cell Proteomics, 7(3): 582-90, 2008  (IF 8.834)

  4. Li J*, Zhang C*, Xu X*, Wang J, Yu H, Lai R, Gong W. Trypsin inhibitory loop is an excellent leadstucture to design serine protease inhibitors and antimicrobial peptides. The FASEB Journal, 21(10): 2466-73, 2007  (IF 7.2)

  5. Xu X, Oliveira F, Chang BW, Collin N, Gomes R, Teixeira C, Reynoso D, Pham VM, Elnaiem DE,Kamhawi S, Ribeiro JM, Valenzuela JG, Andersen JFStructure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection.J Biol Che 286(37): 32383-93, 2011(IF: 5.328)

  6. Xu X, Francischetti IM, Lai R, Ribeiro JM, Andersen JF. Structure of protein having inhibitory disintegrin and leukotriene scavenging functions contained in single domain. J Biol Chem, 287(14): 10967-76, 2012(IF: 4.773)

  7. Ma D*, Xu X*, An S, Liu H, Yang X, Andersen JF, Wang Y, Tokumasu F, Ribeiro JM, Francischetti IM, Lai R. A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets αIIbβ3 or αVβ3 and inhibits platelet aggregation and angiogenesis. Thrombosis and Haemostasis, 105(6):1032-45, 2011  (IF: 4.701)

  8. Xu X,Li J, Lu Q, Yang H, Zhang Y, Lai R. Two families of antimicrobial peptide from wasp (Vespa magnifica) venom. Toxicon,  47(2):249-53, 2006 (IF 2.6)

  9. Xu X, Li J, Han Y, Yang H, Liang J, Lu Q, Lai R. Two antimicrobial peptides from skin secretions of rana grahami. Toxicon, 47(4): 459-64, 2006IF 2.6

  10. Xu X, Yang H, Yu H, Li J, Lai R. The mastoparanogen from wasp. Peptides, 27(12):3053-7, 2006IF 2.6

  11. Yang H*, Xu X*, Ma D, Zhang K, Lai R. A phospholipase A1 platelet activator from the wasp venom of Vespa magnifica (Smith). Toxicon, 51(2):289-96, 2008 IF: 2.46

  12. Li J*,Xu X*, Yu H, Yang H, Huang Z, Lai R. Direct antimicrobial activities of PR-bombesin. Life Sciences, 78(17):1953-6, 2006 IF 1.6

  13. Ma DWang YYang HWu JAn SGao LXu XLai R. Anti-thrombosis repertoire of blood-feeding horsefly salivary glands. Mol Cell Proteomics. Mol Cell Proteomics. 8(9): 2071-9, 2009(IF:8.345)

  14. Ma DLi YDong JAn SWang YLiu CYang XYang HXu XLin DLai R. Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanus yao.Allergy,   66(1):101-9, 2011 (IF:6.297)

  15. An S, Chen L, Wei JF, Yang X, Ma D, Xu X,Xu X, He S, Lu J, Lai R. Purification and characterization of two new allergens from the venom of Vespa magnifica. PLoS One, 7(2): e31920, 2012IF: 4.1

  16. Li JWu HHong JXu XYang HWu BWang YZhu JLai RJiang XLin DPrescott MCRees HH. Odorranalectin is a small peptide lectin with potential for drug delivery and targeting. PLoS One, .3(6):e2381, 2008 (IF 4.41)

  17. Li JWu JWang YXu XLiu TLai RZhu H. A small trypsin inhibitor from the frog of Odorrana grahami. Biochimie, 90(9):1356-61, 2008  (IF 3.071)

  18. Ma DGao LAn SSong YWu J,Xu XLai R. A horsefly saliva antigen 5-like protein containing RTS motif is an angiogenesis inhibitor. Toxicon. 55(1): 45-51, 2010(IF 2.451)

  19. Qi ZPan CLu HShui YLi LLi X,Xu XLiu SJiang SA recombinant mimetics of the HIV-1 gp41 prehairpin fusion intermediate fused with human IgG Fc fragment elicits neutralizing antibody response in the vaccinated mice. Biochem Biophys Res Commun, 398(3):506-12, 2010(IF: 2.595)

  20. Han JYou DXu XHan WLu YLai RMeng Q. An anticoagulant serine protease from the wasp venom of Vespa magnifica. Toxicon, 51(5): 914-22, 2008 (IF 2.46)

  21. Che Q, Zhou Y, Yang H, Li J,Xu X, Lai R. A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahami. Peptides, 29(4):529-35, 2008 (IF 2.654)

  22. Chen LLi YLi JXu XLai RZou Q. An antimicrobial peptide with antimicrobial activity against Helicobacter pylori. Peptides, 28(8):1527-31, 2007  (IF 2.654)

  23. Li J, Yu H, Xu X,Wang X, Liu D, Lai R. Multiple bombesin-like peptides with opposite functions from skin of Odorrana grahami. Genomics, 89(3):413-8, 2007 (IF 3.327)  

  24. Wang XSong YLi JLiu HXu X,Lai RZhang K. A new family of antimicrobial peptides from skin secretions of Rana pleuraden. Peptides, 28(10):2069-74, 2007(IF 2.654)

  25.  Lu YLi JYu HXu XLiang JTian YMa DLin GHuang GLai R. Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis,Peptides, 27(12):3085-91, 2006IF 2.46

  26. Li J, Liu T, Xu X, Wang X, Wu M, Yang H, Lai R. Amphibian tachykinin precursor, Biochemical and Biophysical Research Communications, 350(4): 983-6, 2006 (IF 2.9)

  27. Liang JHan YLi JXu XRees HHLai R. A novel bradykinin -peptide from skin secretions of rufous-spotted torrent frog, Amolops loloensis. Peptides, 27(11):2683-7, 2006IF 2.46

  28. Yu D, Sheng Z, Xu X,Li J, Yang H, Liu Z, Rees HH, Lai R. A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis. Peptides, 27(1):31-5, 2006IF 2.46

  29. Zhou Z, Yang H, Xu X,Wang XLai R. The first report of kininogen from invertebrates. Biochem Biophys Re, s Commun347(4):1099-102, 2006IF 2.648

 

Patents:

  1. A method purifying neuropeptide from the hard tick, Ixodes sinensis and this peptide application in the pharmacy(CN200510010665.1)

  2. An antimicrobial peptide gene of rufous-spotted torrent frog, Amolops loloensis and its application in the pharmacy(CN200610010627.0)

  3. An bioactive peptide gene of rufous-spotted torrent frog, Amolops loloensis and its application in the pharmacy(CN200610010628.5)

  4. A method purifying peptide promoting the release of insulin from Odorrana grahami and its application in the pharmacy (CN200610010770. X)

  5. The method and application of an antimicrobial peptide from wasp( CN200510010664.7)

  6. The gene and mutants of cyclo-Phe-Arg-peptide from from Odorrana grahami (CN200610010931.5)

  7. A Serine protease inhibitor from Odorrana grahami and its application in the pharmacy(ZL 200610010930.0)

  8. A antibacterial peptide from Odorrana grahami(ZL 200610010928.3).

, ONG>Xu X, Han W, Lu Y, Lai R, Meng Q. An anticoagulant serine protease from the wasp venom of Vespa magnifica. Toxicon, 51(5): 914-22, 2008 (IF 2.46)

  • Che Q, Zhou Y, Yang H, Li J,Xu X, Lai R. A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahamiPeptides, 29(4):529-35, 2008 (IF 2.654)

  • Chen LLi YLi JXu XLai RZou Q. An antimicrobial peptide with antimicrobial activity againstHelicobacter pylori. Peptides, 28(8):1527-31, 2007  (IF 2.654)

  • Li J, Yu H, Xu X,Wang X, Liu D, Lai R. Multiple bombesin-like peptides with opposite functions from skin of Odorrana grahamiGenomics, 89(3):413-8, 2007 (IF 3.327)  

  • Wang XSong YLi JLiu HXu X,Lai RZhang K. A new family of antimicrobial peptides from skin secretions of Rana pleuradenPeptides, 28(10):2069-74, 2007(IF 2.654)

  •  Lu YLi JYu HXu XLiang JTian YMa DLin GHuang GLai R. Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis,Peptides, 27(12):3085-91, 2006IF 2.46

  • Li J, Liu T, Xu X, Wang X, Wu M, Yang H, Lai R. Amphibian tachykinin precursor, Biochemical and Biophysical Research Communications, 350(4): 983-6, 2006 (IF 2.9)

  • Liang JHan YLi JXu XRees HHLai R. A novel bradykinin -peptide from skin secretions ofrufous-spotted torrent frog, Amolops loloensisPeptides, 27(11):2683-7, 2006IF 2.46

  • Yu D, Sheng Z, Xu X,Li J, Yang H, Liu Z, Rees HH, Lai R. A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensisPeptides, 27(1):31-5, 2006IF 2.46

  • Zhou Z, Yang H, Xu X,Wang XLai R. The first report of kininogen from invertebrates. BiochemBiophys Res Commun347(4):1099-102, 2006IF 2.648

    授权发明专利

    CURRICULUM VITAE

    Xueqing Xu

    Contact Information:

    Schoolof PharmaceuticalSciences,

    SouthernMedical University,

    Guangzhou, China

    Cell phone: 13928746164 15384419341

    Email: xxueqing@yahoo.com.cn

     

    Education and Career:

     

    Awards

    1.Young Teacher Award conferred by Fok Ying-Tung Education Foundation Committee and China Education department in 2010

    2.Special award for Outstanding Scientific and Technological Thesis conferred by YunnanProvince Scientific Associationin 2010

    3.  Research Excellence Award conferred by the Academic Committee of the Yunnan Province of China in 2008

    4. Advanced worker Awardconferred by Southern Medical University  in 2008

    5. Excellence Award of the Yuanzhang Scholarship conferred by The Chinese Academy of Sciences in 2007

     

    Grants:

     

    Research Experiences:

     

    Teaching jobs

     

    Publications(* co-first author):

     

    Patents:

    , ONG>Xu XHan WLu YLai RMeng Q. An anticoagulant serine protease from the wasp venom of Vespa magnificaToxicon, 51(5): 914-22, 2008 (IF 2.46)

    1. A method purifying neuropeptide from the hard tick, Ixodes sinensis and this peptide application in the pharmacy(CN200510010665.1)

    2. An antimicrobial peptide gene of rufous-spotted torrent frog, Amolops loloensis and its application in the pharmacy(CN200610010627.0)

    3. An bioactive peptide gene of rufous-spotted torrent frog, Amolops loloensis and its application in the pharmacy(CN200610010628.5)

    4. A method purifying peptide promoting the release of insulin from Odorrana grahami and its application in the pharmacy (CN200610010770. X)

    5. The method and application of an antimicrobial peptide from wasp( CN200510010664.7)

    6. The gene and mutants of cyclo-Phe-Arg-peptide from from Odorrana grahami (CN200610010931.5)

    7. A Serine protease inhibitor from Odorrana grahami and its application in the pharmacy(ZL 200610010930.0)

    8. A antibacterial peptide from Odorrana grahami(ZL 200610010928.3).

    1. Xu XChang BWMans BJRibeiro JMAndersen JF. The structure and ligand-binding properties of the biogenic amine-binding protein from saliva of a blood-feeding insect vector ofTrypanosoma cruziActa Crystallogr D Biol Crystallogr69(Pt 1): 105-13. 2013.(IF: 12.619)

    2. Li J*, Xu X*Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J. Anti-infection peptidomics of amphibian skin. Mol Cell Proteomics, 6(5):882-94, 2007IF 9.425

    3. Xu X,Yang H, Ma D, Wu J, Wang Y, Song Y, Wang X, Lu Y, Yang J, Lai R. Toward an understanding of the molecular mechanism for successful blood feeding by coupling proteomics analysis with pharmacological testing of horsefly salivary glands. Mol Cell Proteomics, 7(3): 582-90, 2008  (IF 8.834)

    4. Li J*, Zhang C*, Xu X*, Wang J, Yu H, Lai R, Gong W. Trypsin inhibitory loop is an excellent leadstucture to design serine protease inhibitors and antimicrobial peptides. The FASEB Journal, 21(10): 2466-73, 2007  (IF 7.2)

    5. Xu X, Oliveira F, Chang BW, Collin N, Gomes R, Teixeira C, Reynoso D, Pham VM, Elnaiem DE,Kamhawi S, Ribeiro JM, Valenzuela JG, Andersen JFStructure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection.J Biol Che 286(37): 32383-93, 2011(IF: 5.328)

    6. Xu X, Francischetti IM, Lai R, Ribeiro JM, Andersen JF. Structure of protein having inhibitory disintegrin and leukotriene scavenging functions contained in single domain. J Biol Chem, 287(14): 10967-76, 2012(IF: 4.773)

    7. Ma D*, Xu X*, An S, Liu H, Yang X, Andersen JF, Wang Y, Tokumasu F, Ribeiro JM, Francischetti IM, Lai R. A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets αIIbβ3 or αVβ3 and inhibits platelet aggregation and angiogenesis. Thrombosis and Haemostasis, 105(6):1032-45, 2011  (IF: 4.701)

    8. Xu X,Li J, Lu Q, Yang H, Zhang Y, Lai R. Two families of antimicrobial peptide from wasp (Vespa magnifica) venom. Toxicon,  47(2):249-53, 2006 (IF 2.6)

    9. Xu X, Li J, Han Y, Yang H, Liang J, Lu Q, Lai R. Two antimicrobial peptides from skin secretions of rana grahami. Toxicon, 47(4): 459-64, 2006IF 2.6

    10. Xu X, Yang H, Yu H, Li J, Lai R. The mastoparanogen from wasp. Peptides, 27(12):3053-7, 2006IF 2.6

    11. Yang H*, Xu X*, Ma D, Zhang K, Lai R. A phospholipase A1 platelet activator from the wasp venom of Vespa magnifica (Smith). Toxicon, 51(2):289-96, 2008 IF: 2.46

    12. Li J*,Xu X*, Yu H, Yang H, Huang Z, Lai R. Direct antimicrobial activities of PR-bombesin. Life Sciences, 78(17):1953-6, 2006 IF 1.6

    13. Ma DWang YYang HWu JAn SGao LXu XLai R. Anti-thrombosis repertoire of blood-feeding horsefly salivary glands. Mol Cell Proteomics. Mol Cell Proteomics. 8(9): 2071-9, 2009(IF:8.345)

    14. Ma DLi YDong JAn SWang YLiu C, Yang XYang HXu XLin DLai R. Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanus yao.Allergy,   66(1):101-9, 2011 (IF:6.297)

    15. An S, Chen L, Wei JF, Yang X, Ma D, Xu X,Xu X, He S, Lu J, Lai R. Purification and characterization of two new allergens from the venom of Vespa magnifica. PLoS One, 7(2): e31920, 2012IF: 4.1

    16. Li JWu HHong JXu XYang HWu BWang YZhu JLai RJiang XLin DPrescott MCRees HH. Odorranalectin is a small peptide lectin with potential for drug delivery and targeting. PLoS One, .3(6):e2381, 2008 (IF 4.41)

    17. Li JWu JWang YXu XLiu TLai RZhu H. A small trypsin inhibitor from the frog of Odorrana grahami. Biochimie, 90(9):1356-61, 2008  (IF 3.071)

    18. Ma DGao LAn SSong YWu J,Xu XLai R. A horsefly saliva antigen 5-like protein containing RTS motif is an angiogenesis inhibitor. Toxicon. 55(1): 45-51, 2010(IF 2.451)

    19. Qi ZPan CLu HShui YLi LLi X,Xu XLiu SJiang SA recombinant mimetics of the HIV-1 gp41 prehairpin fusion intermediate fused with human IgG Fc fragment elicits neutralizing antibody response in the vaccinated mice. Biochem Biophys Res Commun, 398(3):506-12, 2010(IF: 2.595)

    20. Han JYou DXu XHan WLu YLai RMeng Q. An anticoagulant serine protease from the wasp venom of Vespa magnifica. Toxicon, 51(5): 914-22, 2008 (IF 2.46)

    21. Che Q, Zhou Y, Yang H, Li J,Xu X, Lai R. A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahami. Peptides, 29(4):529-35, 2008 (IF 2.654)

    22. Chen LLi YLi JXu XLai RZou Q. An antimicrobial peptide with antimicrobial activity against Helicobacter pylori. Peptides, 28(8):1527-31, 2007  (IF 2.654)

    23. Li J, Yu H, Xu X,Wang X, Liu D, Lai R. Multiple bombesin-like peptides with opposite functions from skin of Odorrana grahami. Genomics, 89(3):413-8, 2007 (IF 3.327)  

    24. Wang XSong YLi JLiu HXu X,Lai RZhang K. A new family of antimicrobial peptides from skin secretions of Rana pleuraden. Peptides, 28(10):2069-74, 2007(IF 2.654)

    25.  Lu YLi JYu HXu XLiang JTian YMa DLin GHuang GLai R. Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis,Peptides, 27(12):3085-91, 2006IF 2.46

    26. Li J, Liu T, Xu X, Wang X, Wu M, Yang H, Lai R. Amphibian tachykinin precursor, Biochemical and Biophysical Research Communications, 350(4): 983-6, 2006 (IF 2.9)

    27. Liang JHan YLi JXu XRees HHLai R. A novel bradykinin -peptide from skin secretions of rufous-spotted torrent frog, Amolops loloensis. Peptides, 27(11):2683-7, 2006IF 2.46

    28. Yu D, Sheng Z, Xu X,Li J, Yang H, Liu Z, Rees HH, Lai R. A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis. Peptides, 27(1):31-5, 2006IF 2.46

    29. Zhou Z, Yang H, Xu X,Wang XLai R. The first report of kininogen from invertebrates. Biochem Biophys Res Commun347(4):1099-102, 2006IF 2.648

    1. In fall semester of 2007-2009 and 2012,Speaker in undergraduate required professional course “Biotechnological pharmaceutics”and “antivirial drugs and molecular virology”.

    2. In spring of 2008-2009,Speaker in undergraduate elective courses “Cosmetic Pharmacology”

    1. Structure and function of biologically active salivary proteins from blood-feeding arthropods.

    2. Exploration of proteomics and peptidomics of amphiban skin and wasp venom.

    3. Construction of recombinant virus and Development of the DNA vaccine

    1. Natural Science Foundation of China (NSFC) 30800185, Value:¥200k. Toward an understanding of the molecular mechanism of the grub promoting blood circulation and eliminating of blood stasis. Funding through 2009-2011

    2. Natural Science Foundation of China (NSFC) 31370782, Value:¥800k. Structure basis andmechansim of  fs50, a NaV1.5 inhibitor from the oritental flea (Xenopsylla cheopis (Rots). Funding through 2013-2017

    3. Guangdong Province Education Bureau plan for execllent teacher, Value:¥300k. Structure basis and mechansim of  fs50, a NaV1.5 inhibitor from the oritental flea (Xenopsylla cheopis (Rots). Funding through 2013-2016

    4. Excellent youth plan of southern medical university. Value:¥300k. Structure and function of proteins from the salivary glands of blood-feeding arthropod.   Funding through 2013-2016

    1. 12/2012-present, Associate professor, School of Pharmaceutical Sciences, Southern Medical  University, Guangzhou, China

    2. 09/2012-12/2012, Lecturer, School of Pharmaceutical Sciences, Southern Medical  University, Guangzhou, China

    3. 10/2010-09/2012, Visiting fellow, Laboratory of Malaria and Vector Research NIH/NIAID, Bethesda MD, USA

    4. 05/2009-09/2010, Research associate, Microbiological Department of Medicine School, University of Virginia, Virginia, USA

    5. 07/2007-05/2009, Lecturer, School of Pharmaceutical Sciences, Southern Medical  University, Guangzhou, China

    6. 09/2004-07/2007, Ph.D. in Biochemistry and Molecular Biology, The Department of AnimalToxinologyKunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China

    7. 09/2001-07/2004, M.S. in Veterinary Microbiology and Immunology, The College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

    8. 09/1997-07/2001, B.S. in Veterinary , Hubei Agricultural College, Jingzhou, China

    1. 赖仞,徐学清.胡蜂抗菌肽及其制备方法和应用, 2009.04, 中国,200510010664.7

    2. 赖仞,徐学清,梁建国,韩曜平,杨海龙,李建许棕点湍蛙抗菌肽及其基因和在制药中的应用,2007.11, 中国,200610010627.0

    3. 赖仞,徐学清,梁建国,韩曜平,杨海龙,李建许棕点湍蛙活性多肽及其基因和在制药中的应用,2007.11, 中国,200710010628.3

    4. 赖仞,李健许,徐学清,杨海龙中华硬蜱神经肽及其制备方法和应用,2006.11, 中国,ZL 200510010665.1

    5. 赖仞,李建许,梁建国,徐学清,李东升,李宗杰无指盘臭蛙胰岛素释放促进肽和在制药中的应用,2006.03, 中国,ZL 200610010770.X

    6. 赖仞,李建许,徐春花,李宗杰,吕毅,李东升,徐学清,赖仞无指盘臭蛙丙精肽、基因和变异体,2008.05, 中国,ZL 200610010931.5

    7. 赖仞,李建许,韩曜平,李东升,梁建国,徐学清无指盘臭蛙丝氨酸蛋白酶抑制剂及其应用,2010.01, 中国,ZL 200610010930.0

    8. 赖仞,李建许,徐学清,徐春花,李东升,吕毅无指盘臭蛙抗菌肽2009.08中国,ZL 200610010928.3.

    1. Che Q, Zhou Y, Yang H, Li J,Xu X, Lai R. A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahamiPeptides, 29(4):529-35, 2008 (IF 2.654)

    2. Chen LLi YLi JXu XLai RZou Q. An antimicrobial peptide with antimicrobial activity againstHelicobacter pylori. Peptides, 28(8):1527-31, 2007  (IF 2.654)

    3. Li J, Yu H, Xu X,Wang X, Liu D, Lai R. Multiple bombesin-like peptides with opposite functions from skin of Odorrana grahamiGenomics, 89(3):413-8, 2007 (IF 3.327)  

    4. Wang XSong YLi JLiu HXu X,Lai RZhang K. A new family of antimicrobial peptides from skin secretions of Rana pleuradenPeptides, 28(10):2069-74, 2007(IF 2.654)

    5.  Lu YLi JYu HXu XLiang JTian YMa DLin GHuang GLai R. Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis,Peptides, 27(12):3085-91, 2006IF 2.46

    6. Li J, Liu T, Xu X, Wang X, Wu M, Yang H, Lai R. Amphibian tachykinin precursor, Biochemical and Biophysical Research Communications, 350(4): 983-6, 2006 (IF 2.9)

    7. Liang JHan YLi JXu XRees HHLai R. A novel bradykinin -peptide from skin secretions ofrufous-spotted torrent frog, Amolops loloensisPeptides, 27(11):2683-7, 2006IF 2.46

    8. Yu D, Sheng Z, Xu X,Li J, Yang H, Liu Z, Rees HH, Lai R. A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensisPeptides, 27(1):31-5, 2006IF 2.46

    9. Zhou Z, Yang H, Xu X,Wang XLai R. The first report of kininogen from invertebrates. BiochemBiophys Res Commun347(4):1099-102, 2006IF 2.648

      授权发明专利

       

       

       

       

       

      CURRICULUM VITAE

      Xueqing Xu

      Contact Information:

      Schoolof PharmaceuticalSciences,

      SouthernMedical University,

      Guangzhou, China

      Cell phone: 13928746164 15384419341

      Email: xxueqing@yahoo.com.cn

       

      Education and Career:

       

      Awards

      1.Young Teacher Award conferred by Fok Ying-Tung Education Foundation Committee and China Education department in 2010

      2.Special award for Outstanding Scientific and Technological Thesis conferred by YunnanProvince Scientific Associationin 2010

      3.  Research Excellence Award conferred by the Academic Committee of the Yunnan Province of China in 2008

      4. Advanced worker Awardconferred by Southern Medical University  in 2008

      5. Excellence Award of the Yuanzhang Scholarship conferred by The Chinese Academy of Sciences in 2007

       

      Grants:

       

      Research Experiences:

       

      Teaching jobs

       

      Publications(* co-first author):

       

      Patents:

      1. A method purifying neuropeptide from the hard tick, Ixodes sinensis and this peptide application in the pharmacy(CN200510010665.1)

      2. An antimicrobial peptide gene of rufous-spotted torrent frog, Amolops loloensis and its application in the pharmacy(CN200610010627.0)

      3. An bioactive peptide gene of rufous-spotted torrent frog, Amolops loloensis and its application in the pharmacy(CN200610010628.5)

      4. A method purifying peptide promoting the release of insulin from Odorrana grahami and its application in the pharmacy (CN200610010770. X)

      5. The method and application of an antimicrobial peptide from wasp( CN200510010664.7)

      6. The gene and mutants of cyclo-Phe-Arg-peptide from from Odorrana grahami (CN200610010931.5)

      7. A Serine protease inhibitor from Odorrana grahami and its application in the pharmacy(ZL 200610010930.0)

      8. A antibacterial peptide from Odorrana grahami(ZL 200610010928.3).

      1. Xu XChang BWMans BJRibeiro JMAndersen JF. The structure and ligand-binding properties of the biogenic amine-binding protein from saliva of a blood-feeding insect vector ofTrypanosoma cruziActa Crystallogr D Biol Crystallogr69(Pt 1): 105-13. 2013.(IF: 12.619)

      2. Li J*, Xu X*Xu C, Zhou W, Zhang K, Yu H, Zhang Y, Zheng Y, Rees HH, Lai R, Yang D, Wu J. Anti-infection peptidomics of amphibian skin. Mol Cell Proteomics, 6(5):882-94, 2007IF 9.425

      3. Xu X,Yang H, Ma D, Wu J, Wang Y, Song Y, Wang X, Lu Y, Yang J, Lai R. Toward an understanding of the molecular mechanism for successful blood feeding by coupling proteomics analysis with pharmacological testing of horsefly salivary glands. Mol Cell Proteomics, 7(3): 582-90, 2008  (IF 8.834)

      4. Li J*, Zhang C*, Xu X*, Wang J, Yu H, Lai R, Gong W. Trypsin inhibitory loop is an excellent leadstucture to design serine protease inhibitors and antimicrobial peptides. The FASEB Journal, 21(10): 2466-73, 2007  (IF 7.2)

      5. Xu X, Oliveira F, Chang BW, Collin N, Gomes R, Teixeira C, Reynoso D, Pham VM, Elnaiem DE,Kamhawi S, Ribeiro JM, Valenzuela JG, Andersen JFStructure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection.J Biol Che 286(37): 32383-93, 2011(IF: 5.328)

      6. Xu X, Francischetti IM, Lai R, Ribeiro JM, Andersen JF. Structure of protein having inhibitory disintegrin and leukotriene scavenging functions contained in single domain. J Biol Chem, 287(14): 10967-76, 2012(IF: 4.773)

      7. Ma D*, Xu X*, An S, Liu H, Yang X, Andersen JF, Wang Y, Tokumasu F, Ribeiro JM, Francischetti IM, Lai R. A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets αIIbβ3 or αVβ3 and inhibits platelet aggregation and angiogenesis. Thrombosis and Haemostasis, 105(6):1032-45, 2011  (IF: 4.701)

      8. Xu X,Li J, Lu Q, Yang H, Zhang Y, Lai R. Two families of antimicrobial peptide from wasp (Vespa magnifica) venom. Toxicon,  47(2):249-53, 2006 (IF 2.6)

      9. Xu X, Li J, Han Y, Yang H, Liang J, Lu Q, Lai R. Two antimicrobial peptides from skin secretions of rana grahami. Toxicon, 47(4): 459-64, 2006IF 2.6

      10. Xu X, Yang H, Yu H, Li J, Lai R. The mastoparanogen from wasp. Peptides, 27(12):3053-7, 2006IF 2.6

      11. Yang H*, Xu X*, Ma D, Zhang K, Lai R. A phospholipase A1 platelet activator from the wasp venom of Vespa magnifica (Smith). Toxicon, 51(2):289-96, 2008 IF: 2.46

      12. Li J*,Xu X*, Yu H, Yang H, Huang Z, Lai R. Direct antimicrobial activities of PR-bombesin. Life Sciences, 78(17):1953-6, 2006 IF 1.6

      13. Ma DWang YYang HWu JAn SGao LXu XLai R. Anti-thrombosis repertoire of blood-feeding horsefly salivary glands. Mol Cell Proteomics. Mol Cell Proteomics. 8(9): 2071-9, 2009(IF:8.345)

      14. Ma DLi YDong JAn SWang YLiu C, Yang XYang HXu XLin DLai R. Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanus yao.Allergy,   66(1):101-9, 2011 (IF:6.297)

      15. An S, Chen L, Wei JF, Yang X, Ma D, Xu X,Xu X, He S, Lu J, Lai R. Purification and characterization of two new allergens from the venom of Vespa magnifica. PLoS One, 7(2): e31920, 2012IF: 4.1

      16. Li JWu HHong JXu XYang HWu BWang YZhu JLai RJiang XLin DPrescott MCRees HH. Odorranalectin is a small peptide lectin with potential for drug delivery and targeting. PLoS One, .3(6):e2381, 2008 (IF 4.41)

      17. Li JWu JWang YXu XLiu TLai RZhu H. A small trypsin inhibitor from the frog of Odorrana grahami. Biochimie, 90(9):1356-61, 2008  (IF 3.071)

      18. Ma DGao LAn SSong YWu J,Xu XLai R. A horsefly saliva antigen 5-like protein containing RTS motif is an angiogenesis inhibitor. Toxicon. 55(1): 45-51, 2010(IF 2.451)

      19. Qi ZPan CLu HShui YLi LLi X,Xu XLiu SJiang SA recombinant mimetics of the HIV-1 gp41 prehairpin fusion intermediate fused with human IgG Fc fragment elicits neutralizing antibody response in the vaccinated mice. Biochem Biophys Res Commun, 398(3):506-12, 2010(IF: 2.595)

      20. Han JYou DXu XHan WLu YLai RMeng Q. An anticoagulant serine protease from the wasp venom of Vespa magnifica. Toxicon, 51(5): 914-22, 2008 (IF 2.46)

      21. Che Q, Zhou Y, Yang H, Li J,Xu X, Lai R. A novel antimicrobial peptide from amphibian skin secretions of Odorrana grahami. Peptides, 29(4):529-35, 2008 (IF 2.654)

      22. Chen LLi YLi JXu XLai RZou Q. An antimicrobial peptide with antimicrobial activity against Helicobacter pylori. Peptides, 28(8):1527-31, 2007  (IF 2.654)

      23. Li J, Yu H, Xu X,Wang X, Liu D, Lai R. Multiple bombesin-like peptides with opposite functions from skin of Odorrana grahami. Genomics, 89(3):413-8, 2007 (IF 3.327)  

      24. Wang XSong YLi JLiu HXu X,Lai RZhang K. A new family of antimicrobial peptides from skin secretions of Rana pleuraden. Peptides, 28(10):2069-74, 2007(IF 2.654)

      25.  Lu YLi JYu HXu XLiang JTian YMa DLin GHuang GLai R. Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis,Peptides, 27(12):3085-91, 2006IF 2.46

      26. Li J, Liu T, Xu X, Wang X, Wu M, Yang H, Lai R. Amphibian tachykinin precursor, Biochemical and Biophysical Research Communications, 350(4): 983-6, 2006 (IF 2.9)

      27. Liang JHan YLi JXu XRees HHLai R. A novel bradykinin -peptide from skin secretions of rufous-spotted torrent frog, Amolops loloensis. Peptides, 27(11):2683-7, 2006IF 2.46

      28. Yu D, Sheng Z, Xu X,Li J, Yang H, Liu Z, Rees HH, Lai R. A novel antimicrobial peptide from salivary glands of the hard tick, Ixodes sinensis. Peptides, 27(1):31-5, 2006IF 2.46

      29. Zhou Z, Yang H, Xu X,Wang XLai R. The first report of kininogen from invertebrates. Biochem Biophys Res Commun347(4):1099-102, 2006IF 2.648

      1. In fall semester of 2007-2009 and 2012,Speaker in undergraduate required professional course “Biotechnological pharmaceutics”and “antivirial drugs and molecular virology”.

      2. In spring of 2008-2009,Speaker in undergraduate elective courses “Cosmetic Pharmacology”

      1. Structure and function of biologically active salivary proteins from blood-feeding arthropods.

      2. Exploration of proteomics and peptidomics of amphiban skin and wasp venom.

      3. Construction of recombinant virus and Development of the DNA vaccine

      1. Natural Science Foundation of China (NSFC) 30800185, Value:¥200k. Toward an understanding of the molecular mechanism of the grub promoting blood circulation and eliminating of blood stasis. Funding through 2009-2011

      2. Natural Science Foundation of China (NSFC) 31370782, Value:¥800k. Structure basis andmechansim of  fs50, a NaV1.5 inhibitor from the oritental flea (Xenopsylla cheopis (Rots). Funding through 2013-2017

      3. Guangdong Province Education Bureau plan for execllent teacher, Value:¥300k. Structure basis and mechansim of  fs50, a NaV1.5 inhibitor from the oritental flea (Xenopsylla cheopis (Rots). Funding through 2013-2016

      4. Excellent youth plan of southern medical university. Value:¥300k. Structure and function of proteins from the salivary glands of blood-feeding arthropod.   Funding through 2013-2016

      1. 12/2012-present, Associate professor, School of Pharmaceutical Sciences, Southern Medical  University, Guangzhou, China

      2. 09/2012-12/2012, Lecturer, School of Pharmaceutical Sciences, Southern Medical  University, Guangzhou, China

      3. 10/2010-09/2012, Visiting fellow, Laboratory of Malaria and Vector Research NIH/NIAID, Bethesda MD, USA

      4. 05/2009-09/2010, Research associate, Microbiological Department of Medicine School, University of Virginia, Virginia, USA

      5. 07/2007-05/2009, Lecturer, School of Pharmaceutical Sciences, Southern Medical  University, Guangzhou, China

      6. 09/2004-07/2007, Ph.D. in Biochemistry and Molecular Biology, The Department of AnimalToxinologyKunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China

      7. 09/2001-07/2004, M.S. in Veterinary Microbiology and Immunology, The College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

      8. 09/1997-07/2001, B.S. in Veterinary , Hubei Agricultural College, Jingzhou, China

      1. 赖仞,徐学清.胡蜂抗菌肽及其制备方法和应用, 2009.04, 中国,200510010664.7

      2. 赖仞,徐学清,梁建国,韩曜平,杨海龙,李建许棕点湍蛙抗菌肽及其基因和在制药中的应用,2007.11, 中国,200610010627.0

      3. 赖仞,徐学清,梁建国,韩曜平,杨海龙,李建许棕点湍蛙活性多肽及其基因和在制药中的应用,2007.11, 中国,200710010628.3

      4. 赖仞,李健许,徐学清,杨海龙中华硬蜱神经肽及其制备方法和应用,2006.11, 中国,ZL 200510010665.1

      5. 赖仞,李建许,梁建国,徐学清,李东升,李宗杰无指盘臭蛙胰岛素释放促进肽和在制药中的应用,2006.03, 中国,ZL 200610010770.X

      6. 赖仞,李建许,徐春花,李宗杰,吕毅,李东升,徐学清,赖仞无指盘臭蛙丙精肽、基因和变异体,2008.05, 中国,ZL 200610010931.5

      7. 赖仞,李建许,韩曜平,李东升,梁建国,徐学清无指盘臭蛙丝氨酸蛋白酶抑制剂及其应用,2010.01, 中国,ZL 200610010930.0

      8. 赖仞,李建许,徐学清,徐春花,李东升,吕毅无指盘臭蛙抗菌肽2009.08中国,ZL 200610010928.3.